RNA binding and inhibition of primer extension by a Ru(III)/Pt(II) metal complex.
نویسندگان
چکیده
AH197, a trinuclear Ru(III)/Pt(II) metal complex, is strikingly more effective than the hallmark anticancer drug cisplatin and the Ru(III) clinical candidate NAMI-A in its binding to RNA and inhibition of primer DNA synthesis. Heteromultinuclear complexes could potentially serve as far better chemotherapeutics than mononuclear complexes.
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عنوان ژورنال:
- Chemical communications
دوره 49 44 شماره
صفحات -
تاریخ انتشار 2013